Anti-cancer immune response can be conceptualized as a series of stepwise events referred to as the Cancer-Immunity Cycle. TIP (Tracking Tumor Immunophenotype) is a meta-server which integrates systematically two existing third party methods 'ssGSEA' and 'CIBERSORT' for tracking, analyzing and visualizing the status of anti-cancer immunity and the proportion of tumor-infiltrating immune cells across seven-step Cancer-Immunity Cycle using RNA-seq or Microarray data.

Profiling the status of anti-cancer immunity across seven-step Cancer-Immunity Cycle including release of cancer cell antigens (Step 1), cancer antigen presentation (Step 2), priming and activation (Step 3), trafficking of immune cells to tumors (Step 4), infiltration of immune cells into tumors (Step 5), recognition of cancer cells by T cells (Step 6) and killing of cancer cells (Step 7).

Inferring the proportion of various tumor-infiltrating immune cells such as T cells, B cells, DCs, NK cells, macrophages.

Analyzing the status of anti-cancer immunity and the proportion of tumor-infiltrating immune cells for 11373 patients across 33 TCGA human cancers as the reference tumor immunophenotype profiling.

If you use TIP in your work, please cite our publication:
TIP: A Web Server for Resolving Tumor Immunophenotype Profiling. Cancer Research. 2018.