Welcome to TIP -- Tracking Tumor Immunophenotype
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Introduction for TIP
Anti-cancer immune response can be conceptualized as a series of stepwise events referred to as the Cancer-Immunity Cycle. TIP (Tracking Tumor Immunophenotype) is a meta-server which integrates systematically two existing third party methods 'ssGSEA' and 'CIBERSORT' for tracking, analyzing and visualizing the status of anti-cancer immunity and the proportion of tumor-infiltrating immune cells across seven-step Cancer-Immunity Cycle using RNA-seq or Microarray data.
What can users do in TIP
Profiling the status of anti-cancer immunity across seven-step Cancer-Immunity Cycle including release of cancer cell antigens (Step 1), cancer antigen presentation (Step 2), priming and activation (Step 3), trafficking of immune cells to tumors (Step 4), infiltration of immune cells into tumors (Step 5), recognition of cancer cells by T cells (Step 6) and killing of cancer cells (Step 7).
Inferring the proportion of various tumor-infiltrating immune cells such as T cells, B cells, DCs, NK cells, macrophages.
Analyzing the status of anti-cancer immunity and the proportion of tumor-infiltrating immune cells for 11373 patients across 33 TCGA human cancers as the reference tumor immunophenotype profiling.
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Signature sets
Signature set Genes
Release of cancer cell antigens 39
Cancer antigen presentation 36
Priming and activation 62
Trafficking of immune cells to tumors 76
Infiltration of immune cells into tumors 9
Recognition of cancer cells by T cells 25
Killing of cancer cells 25
Tumor-infiltrating immune cells
T cells CD8 naive NK cells activated
T cells CD8 memory Monocytes CD16
T cells CD8 effector Monocytes CD14
T cells CD4 naive Macrophages M0
T cells CD4 memory resting Macrophages M1
T cells CD4 memory activated Macrophages M2
T helper cell (Th) Dendritic cells resting
T regulatory cell (Treg) Dendritic cells activated
T cells gamma delta pDC
B cells naive Mast cells resting
B cells memory Mast cells activated
Plasma cells Eosinophils
NK cells resting Neutrophils
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